Some Great Anime Couples?

Yukito x Misuzu from Air (my personal favorite)
Tomoya x Nagisa from Clannad
Otanashi x Kanade from Angel Beats!
Train x Saya from Black Cat (this would have happened if...well, as River Song would say, "spoilers")
Yorito x Matsuri from Sola
Matsuda x Sayu from Death Note (not a real couple, just a good one)

Kirito-x-Asuna (SAO)
Daisuke-x-Riku (D.N Angel)
Erza-x-Jellal (Fairytail)
Soushi-x-Ririchiyo (InuXBoku SS)
Sawako-x-Kazehaya (Kimi ni Todoke)
Haru-x-Shizuku (Tonari no Kaibutsu-kun)

Hei & Yin [Darker Than BLACK]
Vincent & Re-L [Ergo Proxy] ~picture~
Koyuki & Maho [BECK Mongolian Chop Squad]
Renton & Eureka [Eureka 7]
Yorito & Matsuri [Sola]
Yukio & Misuzu [AIR TV]
Chrno & Rossette [Chrno Crusade]

Saeko Busujima and Takashi Komuro (HOTD)

Asuna x Kirito from Sword Art Online
Germany x Italy from Hetalia
Road x Allen from D-Gray Man
Sebastian x Ciel from Black Butler
Lavi x Lenalee from D-Gray Man
Hungary x Prussian from Hetalia
America x United Kingdom from Hetalia
Tsuna x Chrome from Katekyo Hitman Reborn !
Sakura x Syaoran from Tsubasa : Reservoir Chronicles
Sakura x Syaoran from Card Captor Sakura
Gajeel x Levy from Fairy Tail
Jellal x Erza from Fairy Tail
Natsu x Lucy from Fairy Tail
Otonashi x Kanade from Angel Beats
Akiza x Yusei from Yu-Gi-Oh 5ds

Junko and Kyosuke (NANA) Please put them in they are awesome!
Ranma and Akane (Ranma 1/2)
18 and Krillin (Dragon Ball Z)

Nagisa x Tomoya
Tsumiki x Io
Mizutani x Haru
Sawako x Kazehaya