What happens to Misa Amane at the end of Death Note is different in the anime, manga, and movie.
At the end of the manga, Misa is last shown staying in the Teito Hotel and then nothing else is ever shown of Misa so it is completely left for mystery what happens to her (in other words, the author never says) but it is certain Misa must've fallen into despair when she eventually learns of Light's death (though the manga never shows this).
At the end of the anime, the director shows Misa standing outside the safety rail at the top of a sky scraper staring off into the sunset. This implies she is about to jump off the sky scraper and kill herself, but the anime never actually shows her committing suicide or anything after the image of her on the sky scraper, so it is still unclear what happened to Misa after that.
At the end of the movie, Misa does not commit suicide. Her memory of the Death Note is gone, but she is still in love with Light and she is last shown in front of a shrine she built in her room for Light celebrating Light's birthday (obsessive much?).
My question to you guys is this: I'd like to hear everyone's opinion on what they think happened to Misa at the end of Death Note. Notice I said opinion since the author never specified what happened to her.
I personally think Misa killed herself, cause I think if the author had written something in the manga about Misa after Light's death, it would have been her committing suicide. She even says in the manga in a much earlier chapter that she couldn't live without Light. That's just my take on it though. What do you guys think?