Fortune Arterial's story revolves around the male protagonist Kohei Hasekura, who transfers into a prestigious public school in the style of an English six-year school encompassing junior-high and high school students. The school, named Shuchikan Academy (修智館学院 Shūchikan Gakuin?), is on an island named Tamatsu Island (珠津島 Tamatsushima?) off-shore from mainland Japan, and the only way to get there is sa pamamagitan ng boat. Soon after transferring, he discovers that one of the students in the class susunod door to his, Erika Sendo, is in fact a type of vampire.