Number 5: Kurama's Death (Elfen Lied)

This one is sad because Nana learns Kurama is only her adopted father. Kurama finds his biological daughter, Mariko, about to die (she has a bomb inside her). So Kurama decides to die with his biological daughter, leaving Nana depressed.

Number 4: Piccolo's Death (Dragonball GT)

In this death, the world is coming to an end, and everyone is being evacuated. Unfortunately, a boy and his dog have been separated from his parents. However, Goku and Piccolo are there! However, Goku is out of energy to use Instant Transmission. Piccolo gives Goku the energy to do...