When the Saiyan arrive a taon later, Piccolo's fondness toward Gohan results in him receiving of one of Nappa's attacks aimed to Gohan, which results in the death of Kami and the Dragon Balls. After the Saiyans are defeated, Gohan and others travel to Piccolo's homeworld Namek to revive those who died against the Saiyans with the Namekian Dragon Balls. Piccolo is resurrected on Planet Namek to help Goku and others defeat the evil Frieza. Despite his massive power increase and going head to head with Frieza's segundo tranformation, Frieza tranforms and Piccolo is defeated and severely injured sa pamamagitan ng Frieza, leaving Goku to defeat him alone. Piccolo is restored to health, and waits a taon until Goku arrives back on Earth. He then trains with Goku and Gohan for three years to prepare for a battle against two powerful androids created sa pamamagitan ng the Red Ribbon to kill Goku.
After being defeated sa pamamagitan ng Android #17 and Android #18, Piccolo seeks to unite with Kami, and gain another massive increase in power. After uniting with Kami, Piccolo becomes aware of a madami dangerous threat named Cell. Before his segundo encounter with Cell, Piccolo once again battles the androids, except this time he battles #17 one on one. After a somewhat even match, Cell arrives on the battle scene and needing to absorb the androids to complete his power, Piccolo is nearly killed sa pamamagitan ng Cell, and he is forced to participate in a Martial Arts Tournament created sa pamamagitan ng Cell called the Cell Games where he fights one of the seven Cell Juniors that are created sa pamamagitan ng Cell, who are later destroyed sa pamamagitan ng Gohan.
Seven years later, Piccolo acts as a trainer to Son Goten, Goku's segundo son, and Trunks, Vegeta's son, and their fused form Gotenks. Piccolo trains the boys in fighting the evil creature Majin Buu, but is later absorbed sa pamamagitan ng Buu along with Gotenks and Gohan and incorporated into his being. He is later freed sa pamamagitan ng Goku and Vegeta, and he later gives his energy to Goku's Super Spirit Bomb, which Goku uses to defeat Buu once and for all.
In Dragon Ball GT he is severely injured sa pamamagitan ng Gohan while he was possessed sa pamamagitan ng Baby and later dies with Earth in order to destroy the Black bituin Dragon Balls. He goes to Heaven but then requests he is sent to Hell in order to free Goku when he is imprisoned there. He can be seen putting Hell in order and protecting the rulers there. In the final episode, Goku stops in Hell to see Piccolo. He tells Piccolo that he will be leaving and that they are glad they met and teamed up. He also says that he has become a good friend and he will get out of Hell someday. They shake hands and Goku leaves while Piccolo stays behind.
