Originally Jensen Ackles auditioned for the role of Sam Winchester. When Jared Padalecki came in and read for Sam a slight recasting was done. Producers called Jensen and asked if he'd rather use his charm for Dean, saying he was the Han Solo character of the duo and what kid didn't grow up wanting to be Han Solo? Jensen accepted. It became known that he was previously interested in that role, because Dean was funny.
Riverview Hospital, a large mental health facility used as the main set in the season 1 episode Asylum, has also substituted for a prison, a regular hospital, and an apartment building on different episodes of the show. This is evidenced sa pamamagitan ng seeing the same distinctive staircase in different episodes.
The Latin inscription on the barrel of the bisiro says 'non timebo mala', which translates to 'I will fear no evil'.
Jeffrey Dean morgan (John Winchester) is only 12 years older than his on-screen oldest son, Jensen Ackles (Dean Winchester).
Both Jensen Ackles and Jared Padalecki grew up in Texas - Jensen in Richardson, and Jared in San Antonio.