Well it really depends on which show/movie your looking at , Im Twilight its because the Bampira kill people and the mga lobo are the protectors but in vampire diares its because there both uncontrollable things so really it depends but form all the fiction things i have read over the years its madami of just a mortal enemy type thing that there naturaly born to kill each other
The mga asong lobo came into existence as protectors of their tribe. Then a pair of Bampira attacked the tribe and another neighbouring tribe. Those Bampira were the most dangerous enemies the mga lobo had ever fought. They've been natural enemies ever since.